Which is BETTER for gout indomethacin or naproxen?

Which is BETTER for gout indomethacin or naproxen?

December 29, 2017 Q&A on Gout 0

How much have you spent for maintenance meds for your gout? Surely, the pain gout produces is more than enough. What more if a painful pocket will add to the agony?

The bitter truth is, it is not the cost of the medications that matter here. It is their ineffectiveness. Let  us get this straight to the point: there is no medication that can cure your gout. However, there are medications that can mask the pains and symptoms. Two such medications are indomethacin and naproxen. The question is, which of them is better when it comes to managing the pain and inflammation caused by gout?


Both naproxen and indomethacin fall under a category of drugs known as Non-Steroidal Anti-Inflammatory Drugs. As the name itself suggests, they are both designed to reduce the inflammation. Take note that this means that they simply remove the pain and inflammation and not remove the cause of your problem, which is uric acid. The main difference between the two is their degree of side effects.

Side Effects of Indomethacin and Naproxen

As NSAIDS, they have a fair share of the side effects of other NSAIDS, mainly peptic ulcer and gastrointestinal bleeding, and even fatal cardiovascular effects. So if you are okay with bleeding inside out just to temporarily take away the pain, go ahead and take one of them. Naproxen is slightly better than indomethacin because the latter is known to cause more severe cases of side effects.

Both of these medications, along with any other medications out there, only masks the symptoms. If you plan to solve your gout problem once and for all, you should think out of the box, open your mind, and flush the uric acid out.

Mechanism of Action of Indomethacin and Naproxen

Now let us go in-depth and analyze these two medications. How do they work? What causes their side effects?

Unlike other medications out there, the side effects of NSAIDs can be explained by studying their mechanism, not just by looking at the numbers of the patients that fell prey to their side effects.

NSAIDs inhibit the production of the enzymes COX-1 and COX-2, which are responsible for converting arachidonic acids into prostaglandins. Since prostaglandins are responsible for causing pain and inflammation as defense mechanisms, you will not experience pain and swelling when it is not produced. Unfortunately, this will leave your body vulnerable to attacks. A house without an alarm system is a much easier victim for thieves, than a house with a full security system. In short, taking either indomethacin and naproxen can cause the suppression of your immune system thus leaving you defenseless against bacterias, viruses and other foreign entities. This is especially true when it comes to indomethacin, because indomethacin maims the white blood cells so it will not respond to foreign invasions (such as the uric acid crystals) and will therefore not cause pain.

Lastly, all NSAIDS cause peptic ulcer and gastrointestinal bleeding because prostaglandins are also responsible for the maintenance of mucus lining of the stomach. Needless to say, if you disable the production of prostaglandins, you disable the maintenance of the mucus lining eventually leading to ulcer or even bleeding.


Naproxen is slightly better than indomethacin because it has a relatively less severe side effect. However, this does not change the fact that both of them can not cure your gout. Neither of them focus on the root cause of gout, which is uric acid. You can take them for as long as you like, along with other medications out there, but it will do you no good. Sooner or later you will find yourself looking for a solution to the root cause of gout.

Are you tired of being awakened late midnight by the burning inflammation of gout? Are you tired of the everyday obstruction caused by inflamed joints? Or maybe you are tired of horrifying cries of pain from the people you love who suffer from gout? You are missing a lot of things because of the restraints of gout. You want freedom? Worry no more. There is a natural yet effective approach in eliminating those problems. Mark my words: kill the roots and the grass will no longer grow. Eliminate acidosis and cure your gout!

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